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Statins Lower Coenzyme Q-10 (Ubiquinone) and Must be Replaced
Statin Facts
1). Statins lower coenzyme Q-10 levels due to synthesis inhibition (PMID: 8463436, 2247468, 14757233)
2). Lower coenzyme Q-10 levels are related to muscle pain, congestive heart failure and liver toxicity (PMID: 15210526, 12847998)
3). A major drug company has patented combination statin and coenzyme Q-10 to prevent muscle pain and liver toxicity
4). Canada has forced the statin makers to warn of the coenzyme Q-10 deficiencies
5). Exercise intolerance and myalgia are common side effects of the statins
6). Adding coenzyme Q-10 to the statin reduces problems associated with their use (PMID: 8877024

Suggestion: Compound 100 mg of coenzyme Q-10 into all statin prescriptions filled

What is claimed is in patented combination containing statin and coenzyme Q-10:

1. A pharmaceutical composition comprising a pharmaceutical carrier and an effective antihypercholesterolemic amount of an HMG-CoA reductase inhibitor and an amount of Coenzyme Q.sub.10 effective to counteract HMG-CoA reductase inhibitor-associated skeletal muscle myopathy.
2. A composition of claim 1 in which the HMG-CoA reductase inhibitor is selected from: lovastatin, simvastatin, pravastatin and sodium-3,5-dihydroxy-7-[3-(4-fluorophenyl)-1-(methylethyl)-1H-Indole-2yl]- hept-6-enoate.
3. A method of counteracting HMG-CoA reductase inhibitor-associated skeletal muscle myopathy in a subject in need of such treatment which comprises the adjunct administration of a therapeutically effective amount of an HMG-CoA reductase inhibitor and an effective amount of Coenzyme Q.sub.10 to counteract said myopathy.
4. A method of claim 3 in which the HMG-CoA reductase inhibitor is selected from the group consisting of: lovastatin, simvastatin, pravastatin and sodium-3,5-dihydroxy-7-[3-(4-fluorophenyl)-1-(methylethyl)-1H-Indole-2yl]- hept-6-enoate.

A pharmaceutical composition and method of counteracting HMG-CoA reductase inhibitor-associated myopathy is disclosed. The method comprises the adjunct administration of an effective amount of a HMG-CoA reductase inhibitor and an effective amount of Coenzyme Q.sub.10.

Health Warning on Statins
Canadian health authorities require that statins sold in Canada carry a precautionary warning regarding CoQ10 depletion. Pfizer's LipitorĀ® contains the following warning:

The Effect on Ubiquinone
(CoQ10) Levels
"Significant decreases in circulating ubiquinone levels in patients treated with atorvastatin and other statins have been observed. The clinical significance of a potential long-term statin-induced deficiency of ubiquinone has not been established. It has been reported that a decrease in myocardial ubiquinone levels could lead to impaired cardiac function in patients with borderline congestive heart failure . . ."

What you should know prior to obtaining a compounded prescription
We at Soderlund Village Drug make no claim that any compounded prescription is bio-equivalent or therapeutically equivalent to any commercially manufactured drug. We make no claim regarding AUC, C-max, T-max or blood-levels of any compounded prescription. Compounded medications, with a reasonably good therapeutic index, are often dosed to an effect not a blood level. Compounded prescriptions are prescribed to meet the needs of an individual patient because a drug, strength, flavor, combination or dosage form is commercially unavailable.

At Soderlund Village Drug a written prescription from a licensed physician or veterinarian is required for compounded medications to be dispensed by our pharmacy. A valid prescription may be presented in person, faxed, mailed or phoned by a licensed practitioner or their representative/agent. We make no claims of safety or efficacy of any compounded prescription though we will be glad to share pertinent medical studies, published professional knowledge, journal articles and factual antidotal data with any prescriber or patient desiring more information. At Soderlund Village Drug no medication we compound is to be used in any food-producing animals.